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Safety and immunogenicity of a live recombinant Newcastle disease virus-based COVID-19 vaccine (Patria) administered via the intramuscular or intranasal route: Interim results of a non-randomized open label phase I trial in Mexico

Authors: Samuel Ponce-de-León, Martha Torres, Luis Enrique Soto-Ramírez, Juan José Calva, Patricio Santillán-Doherty, Dora Eugenia Carranza-Salazar, Juan Manuel Carreño, Claudia Carranza, Esmeralda Juárez, Laura E Carreto-Binaghi, Luis Ramírez-Martínez, Georgina Paz-De la Rosa, Rosalía Vigueras-Moreno, Alejandro Ortiz-Stern, Yolanda López-Vidal, Alejandro E Macías, Jesús Torres-Flores, Oscar Rojas-Martínez, Alejandro Suárez-Martínez, Gustavo Peralta-Sánchez, Hisaaki Kawabata, Irene González-Domínguez, José Luis Martínez-Guevara, Weina Sun, David Sarfati-Mizrahi, Ernesto Soto-Priante, Héctor Elías Chagoya-Cortés, Constantino López-Macías, Felipa Castro-Peralta, Peter Palese, Adolfo García-Sastre, Florian Krammer, Bernardo Lozano-Dubernard

Journal: medrxiv

PubMed ID: 35169806

Doi: 10.1101/2022.02.08.22270676

Products & Services: Recombinant Proteins

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

Authors: Adam L Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J Scott, Ross A D Bathgate

Journal: Int J Mol Sci

PubMed ID: 35163827

Doi: 10.3390/ijms23031908

Products & Services: cGMP Peptide Synthesis

Colicin E1 opens its hinge to plug TolC

Authors: S Jimmy Budiardjo, Jacqueline J Stevens, Anna L Calkins, Ayotunde P Ikujuni, Virangika K Wimalasena, Emre Firlar, David A Case, Julie S Biteen, Jason T Kaelber, Joanna S G Slusky

Journal: Elife

PubMed ID: 35199644

Doi: 10.7554/eLife.73297

Products & Services: Proteins, Expression, Isolation and Analysis

Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Authors: Zhi Yang, Kim-Marie A Dam, Michael D Bridges, Magnus A G Hoffmann, Andrew T DeLaitsch, Harry B Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A Martin, Michel C Nussenzweig, Wayne L Hubbell, Pamela J Bjorkman

Journal: Nat Commun

PubMed ID: 35136084

Doi: 10.1038/s41467-022-28424-3

Products & Services: Catalog Antibody

CRISPR-dCas9 based DNA detection scheme for diagnostics in resource-limited settings

Authors: Michel Bengtson, Mitasha Bharadwaj, Oskar Franch, Jaco van der Torre, Veronique Meerdink, Henk Schallig, Cees Dekker

Journal: Nanoscale

PubMed ID: 35044397

Doi: 10.1039/d1nr06557b

Products & Services: Plasmid DNA Preparation

An engineered bispecific human monoclonal antibody against SARS-CoV-2

Authors: Zhaohui Li, Shihua Li, Gen Zhang, Weiyu Peng, Zhen Chang, Xue Zhang, Zheng Fan, Yan Chai, Feiran Wang, Xin Zhao, Dedong Li, Rong Zhang, Zhanlong He, Weiwei Zou, Ke Xu, Wenwen Lei, Peipei Liu, Junfeng Hao, Jingjing Zhang, Litao Sun, Guizhen Wu, Shuguang Tan, George Fu Gao, Feng Gao, Yan Wu

Journal: Nat Immunol

PubMed ID: 35228696

Doi: 10.1038/s41590-022-01138-w

Products & Services: Stable Cell Lines

Placental methylome reveals a 22q1333 brain regulatory gene locus associated with autism

Authors: Yihui Zhu, J Antonio Gomez, Benjamin I Laufer, Charles E Mordaunt, Julia S Mouat, Daniela C Soto, Megan Y Dennis, Kelly S Benke, Kelly M Bakulski, John Dou, Ria Marathe, Julia M Jianu, Logan A Williams, Orangel J Gutierrez Fugón, Cheryl K Walker, Sally Ozonoff, Jason Daniels, Luke P Grosvenor, Heather E Volk, Jason I Feinberg, M Daniele Fallin, Irva Hertz-Picciotto, Rebecca J Schmidt, Dag H Yasui, Janine M LaSalle

Journal: Genome Biol

PubMed ID: 35168652

Doi: 10.1186/s13059-022-02613-1

Products & Services: Polyclonal Antibody Services

Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy

Authors: Hung X Nguyen, Tianyu Wu, Daniel Needs, Hengtao Zhang, Robin M Perelli, Sophia DeLuca, Rachel Yang, Michael Tian, Andrew P Landstrom, Craig Henriquez, Nenad Bursac

Journal: Nat Commun

PubMed ID: 35110560

Doi: 10.1038/s41467-022-28251-6

Products & Services: Codon Optimization

Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli

Authors: Zhifeng Liu, Jianlin Xu, Haili Liu, Yong Wang

Journal: Microb Biotechnol

PubMed ID: 35174640

Doi: 10.1111/1751-7915.14000

Products & Services: Codon Optimization

Antibody responses to 2 doses of mRNA Covid vaccine in pediatric renal patients

Authors: Alison Lap-Tak Ma, Daniel Leung, Eugene Yu-Hin Chan, Stella Chim, Samuel Cheng, Fanny Tsz-Wai Ho, Wai-Ming Lai, Pak-Chiu Tong, Matthew Hon-Lam Lee, Wilfred Hing-Sang Wong, Sau Man Chan, Jaime Rosa Duque, Joseph Sriyal Malik Peiris, Yu-Lung Lau

Journal: Kidney Int

PubMed ID: 35231464

Doi: 10.1016/j.kint.2022.01.035

Products & Services: Proteins, Expression, Isolation and Analysis