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Engineered ipilimumab variants that bind human and mouse CTLA-4

Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee

Journal: MAbs

PubMed ID: 39849917

Doi: 10.1080/19420862.2025.2451296

Products & Services: Combinatorial DNA Libraries

Peptide codes for organ-selective mRNA delivery

Authors: Tie Chang, Yifan Zheng, Mingrui Jiang, Siqi Jia, Jianbo Bai, Zhi Zheng, Shixin Li, Jia Guo, Yue Wang, Yiting Wang, Haixia Liu, Jianlin Liu, Liangyu Ni, Xingdi Cheng, Shuai Liu, Huijuan Zhang, Wei Pi, Feng Lin, Shiyi Liu, Weijian Wang, Guannan Wang, Leyun Wang, Lei Miao, Xueguang Lu, Ziqing Deng, Bing Bai, Zhao Qin, Huajian Gao, Yue Shao

Journal: Nature materials

PubMed ID: 40890497

Doi: 10.1038/s41563-025-02331-6

Products & Services: GenCrispr Cas9 Genome Editing

A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses

Authors: Lei Yan, Fulian Wang, Michelle Hill, Juliane Brun, Ze Liang, Xinyu Shi, Liangminghui Zhang, Xiuxiu He, Yu Li, Qianping Huang, Xuxue Dong, Huanzhen Liu, Yi Zhang, Lili Liu, Raymond A Dwek, Nicole Zitzmann, Aibin Liang, Guang Yang

Journal: Nature Communications

PubMed ID: 40813592

Doi: doi.org/10.1038/s41467-025-63101-1

Products & Services: Peptide Synthesis

Biochemical Consequences of a Leucine-to-Cysteine Clamp Substitution in Lipoxygenases

Authors: Samuel G Hill, Katherine DeFeo, Adam R Offenbacher

Journal: Biomolecules

PubMed ID: 40867598

Doi: 10.3390/biom15081153

Products & Services: Gene Synthesis

Proteolysis-triggered RNA Interference for Mitochondrial Iron Dyshomeostasis to Activate Antitumor Immunity in Hepatic Carcinoma

Authors: Shi-Man Zhang, Xiao-Kang Jin, Hong Chen, Yu-Zhang Wang, Jun-Long Liang, Jun Feng, Wei-Hai Chen, Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 40757917

Doi: 10.1002/adma.202508457

Products & Services: Catalog Peptides

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress

Authors: Hui Guan, Liqi Huang, Yu Liu, Enyi Zhu, Lefeng Chen, Weijie Li, Haiqi Wu, Xiaoying Zhang, Rencai Qin, Jingpeng Zheng, Yingqian Mo, Ming Zhong, Bihua Xu, Xiaoyan Dai, Qi Wei, Yunwei Chen, Qingwen Wang, Zhihua Zheng, Kongyang Ma, Chun Tang

Journal: Journal of Inflammation Research

PubMed ID: 106070

Products & Services: Endotoxin Detection & Removal System

Iterative recombinase technologies for efficient and precise genome engineering across kilobase to megabase scales

Authors: Chao Sun, Hongchao Li, Yijing Liu, Jinxing Liu, Ronghong Liang, Caixia Gao

Journal: CELL

PubMed ID: 40763736

Doi: 10.1016/j.cell.2025.07.011

Products & Services: Gene Synthesis

Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Authors: Yang Yue, Chanjuan Xu, Lijie Wu, Man Na, Kexin Xu, Xuan Chen, Yuxuan Song, Sichun Weng, Lu Xu, Fei Li, Xi Lin, Arthur Wang, Jianfeng Liu, Fei Xu

Journal: Nature Communications

PubMed ID: 40790299

Doi: doi.org/10.1038/s41467-025-62870-z

Products & Services: Gene Synthesis

Lactate-Modulating Nanoreactors Facilitate Self-Amplifying Pyroptosis and the cGAS-STING Cascade for Potentiated Catalytic-Immunotherapy

Authors: Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng

Journal: Advanced Science

PubMed ID: 40874418

Doi: 10.1002/advs.202511144

Products & Services: Proteins, Expression, Isolation and Analysis

Aligned Electrospun Fibers Inducing Cell and Nuclear Morphology Remodeling via Ras-Associated Protein 1/Yes-Associated Protein Signaling Enhances Bone Regeneration

Authors: Shengjie Jiang, Jialiang Zhou, Cancan Zhao, Liyun Wang, Zeyu Fu, Mazaher Gholipourmalekabadi, Xudong Wang, Changyong Yuan, Kaili Lin