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Discovery of Novel Potent Muscarinic M3 Receptor Antagonists with Proper Plasma Stability by Structural Recombination of Marketed M3 Antagonists

ChemMedChem. 2017; 
Zuojuan Xiang+ , Jun Liu+ , Hongbin Sun,* and Xiaoan Wen*[a]
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All binding assays were performed in 96-well plates (UniFilter 96 GF/C, PerkinElmer) with membrane preparation expressing human M3 receptors (transfected CHO-K1 cells, GenScript USA Inc.).

摘要

关键词

ammonium salts · antagonists · nitrogen heterocycles · stability · structure–activity relationships