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PE6b

PE6b is a variant of the prime editor protein specifically designed for genome editing in living cells. It enhances the efficiency of genome edits compared to earlier versions of prime editors. Notably, editors like PE6b are smaller in size, allowing for more efficient delivery when used in medical and therapeutic applications.
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 RC00006-30

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Description PE6b is a variant of the prime editor protein specifically designed for genome editing in living cells. It enhances the efficiency of genome edits compared to earlier versions of prime editors. Notably, editors like PE6b are smaller in size, allowing for more efficient delivery when used in medical and therapeutic applications.
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single guide RNA (sgRNA) dependent single-stranded DNA cleavage
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Expression System Recombinant Cas9-based fusion with three NLS expressed by E.coli
Species S. pyogenes
PAM NGG
Tag C-His tag
Molecular Weight 223.780KDa
Storage & Stability PE6b is supplied with storage buffer (50 mM Tris, 300 mM NaCl, 0.1 mM EDTA, 1 mM DTT, 50% Glycerol pH7.5, at 25°C) and recommended to be stored at -80°C.
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Purity ≥90% by SDS-PAGE, 99% by SEC-HPLC
Residual DNase Non-specific DNase activity
Endotoxin Level Control <10EU/mg
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PE6b

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PE6b

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References David R Liu, et al. “Phage-assisted evolution and protein engineering yield compact, efficient prime editors”. Cell. 2023 Aug 31;186(18):3983-4002.e26.
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