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目录产品 » Coagulation Factor II, His, Rat

Coagulation Factor II, His, Rat

Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes an allosteric equilibrium between two alternative conformations, open and closed, that react differently with the physiological activator prothrombinase. It has 10 sites of gamma-carboxylation, which are required for its bioactivity, and is N-glycosylated at three of four putative sites.
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 Z06416-100

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Species Rat
Protein Construction
Coagulation Factor II (Gln25-Arg617)_x000D_
Accession # NP_075213.2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 69.12 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Coagulation Factor II, His, Rat

The purity of Coagulation Factor II, His, Rat is greater than 95% as determined by SEC-HPLC. »

Coagulation Factor II, His, Rat

Coagulation Factor II, His, Rat on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Target Background Prothrombin, or coagulation factor II, is a multidomain zymogen precursor of thrombin that undergoes an allosteric equilibrium between two alternative conformations, open and closed, that react differently with the physiological activator prothrombinase. It has 10 sites of gamma-carboxylation, which are required for its bioactivity, and is N-glycosylated at three of four putative sites.
Synonyms F2; Prothrombin; thrombin; F II; FII
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 For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.