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目录产品 » IL-3 R alpha/CD123 hFc Chimera, Human

IL-3 R alpha/CD123 hFc Chimera, Human

Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
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Species Human
Protein Construction
IL-3 R alpha/CD123 (Thr19-Arg305)
Accession # P26951-1		 hFc
N-term C-term
Purity > 90% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 59.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-3 R Alpha/CD123 HFc Chimera, Human

Immobilized Human IL-3, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for IL-3 R alpha/CD123 hFc Chimera, Human, hFc Tag with the EC50 of 0.46 μg/ml determined by ELISA. »

IL-3 R Alpha/CD123 HFc Chimera, Human

Immobilized IL-3 R alpha/CD123 hFc Chimera, Human, hFc Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-IL-3 R alpha Antibody, hFc Tag with the EC50 of 7.6ng/ml determined by ELISA. »

IL-3 R Alpha/CD123 HFc Chimera, Human

The purity of IL-3 R alpha/CD123 hFc Chimera, Human is greater than 90% as determined by SEC-HPLC. »

IL-3 R Alpha/CD123 HFc Chimera, Human

IL-3 R alpha/CD123 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. »

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Target Background Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily.The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias.
Synonyms CD123; IL-3R subunit alpha; IL3R; IL3RA; IL-3Ra; IL3RAY; IL3RX; IL3RY; MGC34174; IL-3 R alpha
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 For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.